17. Skin & Pain


  • Pain receptors (nociceptors) are widely distributed in the skin and other tissues. 
  • Nociceptors are free nerve endings of sensory Aδ and un-myelinated C nerve fibers, which respond to tissue damage. 
  • Stimulation of the nociceptors by tissue damage results in action potentials in the peripheral nerve fibers.
  • Three types of stimuli can activate pain receptors in peripheral tissues: mechanical (pressure, pinch), heat, and chemical.
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